Carcinomas of the uterine cervix and vagina in estrogen- and androgen-treated hybrid mice.

Carcinomas of the uterine fundus occur more frequently among women showing unusual production of estrogenic hormone than in normal women (15). Although there is less evidence of a correlation of abnormal production of estrogens and tumors of the uterine cervix, at least one investigator has reported that deficiencies of vitamins, with possible coincident impairment of estrogen inactivation, was not unusual in women with precancerous lesions and early cancer of the cervix (2). Invasive epithelial lesions (1, 6) 'precancerous' lesions (3, 10, 14) and carcinomas of the uterine cervix appear in estrogen-treated mice of all strains that have been adequately studied (5, 11, 12). Carcinomas of the cervix rarely occur in mice of most inbred strains, and none have been described that have arisen specifically from the cervix other than in mice from the PM stock, studied recently in this laboratory (9). Tumors of the genital tract of treated and control hybrid mice derived from crossing the PM stock 1 with mice of the C3H strain are reported here.